PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance
نویسنده
چکیده
PPARδ is a ligand-activated nuclear receptor that regulates the transcription of genes associated with proliferation, metabolism, inflammation, and immunity. Within this transcription factor family, PPARδ is unique in that it initiates oncogenesis in a metabolic and tissue-specific context, especially in mammary epithelium, and can regulate autoimmunity in some tissues. This review discusses its role in these processes and how it ultimately impacts breast cancer.
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عنوان ژورنال:
دوره 2016 شماره
صفحات -
تاریخ انتشار 2016